A work by Amin Ahmadi et. al., in Kidney research group of Royan Stem Cell Institute was featured by @Cell Therapy News on tweeter. In this study which was published in the current issue of Scientific Reports, they describe the results of cell therapy of in vitrogenerated podocytes in in vivo model of membranous nephropathy. Injury to podocytes is a principle cause of initiation and progression of glomerular diseases that result in proteinuria and decreased function of the kidney. Thus, there is hope that generation and transplantation of podocytes from induced pluripotent stem cells (iPSCs), could potentially be used as a curative treatment for glomerulonephritis caused by podocytes injury and loss. We showed that transplantation of functional iPSCderived podocytes following podocytes depletion results in recruitment of iPSC-derived podocytes within the damaged glomerulus, and leads to attenuation of proteinuria and histological alterations.The link to the paper can be found : https://www.ncbi.nlm.nih.gov/pubmed/31664077.
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